A major new study has found a potential link between blood type and breast cancer risk, and it’s sparked concern, especially for those with blood type A. The research, which pooled data from 29 separate studies, suggests that people with type A blood may face a higher chance of developing breast cancer compared to those with type O.
The findings come from a large-scale analysis published in Oncotarget, involving over 13,000 breast cancer cases and more than 717,000 controls across continents, including Asia, Europe, Africa, and the Americas. It’s being called the most comprehensive review to date on the topic.
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In their report, the researchers explained, “This meta-analysis is the most extensive review to date on this topic, based on studies conducted across Asia, Europe, Africa, and the Americas.” They added that while earlier research produced mixed results, this new review offers stronger evidence that there could indeed be a biological connection between blood type A and breast cancer.
According to the Cleveland Clinic, Specifically, the study found that people with blood type A were 18% more likely to be diagnosed with breast cancer compared to those with type O. No significant link was found for types B, AB, or the Rh factor, which determines whether blood is positive or negative.
So, what’s going on here? Well, scientists believe the answer might lie in blood group antigens—the molecules that sit on the surface of cells, including those in breast tissue. These antigens could influence how the immune system interacts with cells or affect how those cells behave and grow, which in turn might play a role in cancer development.
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To be clear, this doesn’t mean that having blood type A guarantees you’ll get breast cancer—far from it. The researchers stressed that this is a correlation, not a direct cause-and-effect relationship. Still, spotting these kinds of patterns can be vital in helping experts understand how cancers develop and who might be at increased risk.
They also noted that much more research is needed before any changes in medical advice or screening protocols are considered. But for now, it’s a fascinating—and slightly unnerving—insight into how our genetics might be influencing more than we realise.
With breast cancer remaining one of the most common forms of the disease worldwide, studies like this are a crucial step in staying one step ahead. And if you’re blood type A? Might be time to be a bit more proactive with those regular checks.
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